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Amoxicillin is a drug, a semi-synthetic broad-spectrum antibiotic of the penicillin group. Effective against anaerobic gram-negative and gram-positive microorganisms. In terms of its pharmacological properties, it is close to ampicillin but has better oral bioavailability.
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Amoxicillin indications
The list of applications of the drug Amoxicillin, according to the instruction, is quite wide. It includes:
- ● infections of the upper and lower respiratory tract (otitis, sinusitis, tonsillitis (tonsillitis), acute bronchitis, and pneumonia);
- ● infections of the genitourinary system (pyelonephritis, cystitis, urethritis, endometritis, cervicitis, etc.);
- ● inflammation of the gallbladder;
- ● skin and soft tissue infections;
- ● infections of the gastrointestinal tract;
- ● tick-borne borreliosis;
- ● prevention of bacterial endocarditis during surgical treatment in the oral cavity or in the upper respiratory tract.
Amoxicillin mechanism of action
Amoxicillin is a drug that contains the active substance amoxicillin trihydrate. The substance belongs to the antibiotics of bactericidal action.
The mechanism of action is to destroy the proteins that form the shell of the microorganism. Thus, the bacteria remain unprotected and die under the influence of immunity.
Amoxicillin how to take
The drug can be taken by adults and children, so it is produced in the form of tablets, soluble tablets, capsules, and granules for suspension.
The dosage of Amoxicillin may vary with the disease itself, the weight, and the age of the patient. For adults, this range is 250 mg to 1000 mg every 8 or 12 hours. For children – depending on weight and on the disease, from 20 mg to 100 mg per kilogram of weight.
Side effects
During treatment with this drug, the following side effects may occur:
- ● manifestations associated with an allergic reaction of the body: angioedema, erythema, urticaria, conjunctivitis, rhinitis; in rare cases, the manifestation of pain in the joints, eosinophilia, fever; in very rare cases, anaphylactic shock;
- ● a consequence of chemotherapeutic influence: the development of superinfections, which are most often manifested in people suffering from chronic ailments, and those who have reduced resistance;
- ● a consequence of prolonged use of the drug in large doses: ataxia, dizziness, depression, impaired consciousness, convulsions, peripheral neuropathies, therefore, only a doctor should determine how many days to take the drug;
- ● with a combination of Amoxicillin + Metronidazole: vomiting, nausea, constipation, anorexia, diarrhea, stomatitis, epigastric pain, glossitis; in rare cases, pseudomembranous colitis, hepatitis, allergic manifestations, hematopoiesis disorders, interstitial nephritis may occur;
- ● with a combination of Amoxicillin + Clavulanic acid: hepatitis, cholestatic jaundice; in rare cases – erythema multiforme, exfoliative dermatitis, toxic epidermal necrolysis.
Amoxicillin contraindications
The most important contraindication to the use of Amoxicillin is the patient’s allergy to penicillin or to any other component in the drug.
Also, contraindications include the following diseases:
- ● Infectious mononucleosis;
- ● lymphocytic leukemia;
- ● severe gastrointestinal infections accompanied by diarrhea or vomiting;
- ● respiratory viral infections;
- ● allergic diathesis;
- ● bronchial asthma;
- ● hay fever.
Amoxicillin and alcohol
The intake of alcoholic products in conjunction with antibiotic treatment is not recommended. Since their combination leads to the manifestation of more side effects.
Amoxicillin during pregnancy
Amoxicillin has the ability to penetrate the fetus through the placenta. Therefore, if it is necessary to use an antibiotic during pregnancy, the expected benefit to the mother should be weighed against the possible risks to the fetus. The doctor must first conduct an examination and assess the risks.
Special instructions
Amoxicillin should be used with extreme caution if you are prone to allergic reactions. Persons under 18 years of age and patients suffering from hepatic pathologies are not recommended to use the drug in combination with Metronidazole.
In case of impaired renal function, the drug dose should be reduced, and the intervals between doses should be increased. In the treatment process, it is necessary to constantly monitor the work of the liver, kidneys, and blood-forming organs. To reduce the risk of complications from the digestive tract (nausea, vomiting, diarrhea, flatulence), Amoxicillin is recommended to be taken with meals. Data on the negative effect of drugs on the ability to drive vehicles is not available.
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